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Ion channel gating: insights via molecular simulations.

Abstract:

Ion channels are gated, i.e. they can switch conformation between a closed and an open state. Molecular dynamics simulations may be used to study the conformational dynamics of ion channels and of simple channel models. Simulations on model nanopores reveal that a narrow (<4 A) hydrophobic region can form a functionally closed gate in the channel and can be opened by either a small (approximately 1 A) increase in pore radius or an increase in polarity. Modelling and simulation studies conf...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
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Journal:
FEBS letters
Volume:
555
Issue:
1
Pages:
85-90
Publication date:
2003-11-01
DOI:
EISSN:
1873-3468
ISSN:
0014-5793
Source identifiers:
100195
Language:
English
Keywords:
Pubs id:
pubs:100195
UUID:
uuid:4414d8d2-f01f-424b-ae5d-d9717315b7b1
Local pid:
pubs:100195
Deposit date:
2012-12-19

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