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Journal article

Local field potential beta activity in the subthalamic nucleus of patients with Parkinson's disease is associated with improvements in bradykinesia after dopamine and deep brain stimulation.

Abstract:

Parkinson's disease is treated pharmacologically with dopamine replacement medication and, more recently, by stimulating basal-ganglia nuclei such as the subthalamic nucleus (STN). Depth recordings after this procedure have revealed excessive activity at frequencies between 8 and 35 Hz (Brown et al., 2001; Kuhn et al., 2004; Priori et al., 2004) that are reduced by dopamine therapy in tandem with improvements in bradykinesia/rigidity, but not tremor (Kuhn et al., 2006). It has also been shown...

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Publication status:
Published

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Authors


Jenkinson, N More by this author
Holland, P More by this author
Brittain, JS More by this author
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Journal:
Experimental neurology
Volume:
213
Issue:
1
Pages:
108-113
Publication date:
2008-09-05
DOI:
EISSN:
1090-2430
ISSN:
0014-4886
URN:
uuid:440526e8-80cc-4573-b2c0-75b94cef09e1
Source identifiers:
141649
Local pid:
pubs:141649

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