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Overcoming the challenges of membrane protein crystallography.

Abstract:

Membrane protein structural biology is still a largely unconquered area, given that approximately 25% of all proteins are membrane proteins and yet less than 150 unique structures are available. Membrane proteins have proven to be difficult to study owing to their partially hydrophobic surfaces, flexibility and lack of stability. The field is now taking advantage of the high-throughput revolution in structural biology and methods are emerging for effective expression, solubilisation, purifica...

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Publication status:
Published

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Publisher copy:
10.1016/j.sbi.2008.07.001

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Genomics Consortium
Role:
Author
Journal:
Current opinion in structural biology
Volume:
18
Issue:
5
Pages:
581-586
Publication date:
2008-10-05
DOI:
EISSN:
1879-033X
ISSN:
0959-440X
URN:
uuid:440186a7-c02f-41e9-9209-11db65ff358e
Source identifiers:
72730
Local pid:
pubs:72730

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