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Journal article

Disease model distortion in association studies.

Abstract:

Most findings from genome-wide association studies (GWAS) are consistent with a simple disease model at a single nucleotide polymorphism, in which each additional copy of the risk allele increases risk by the same multiplicative factor, in contrast to dominance or interaction effects. As others have noted, departures from this multiplicative model are difficult to detect. Here, we seek to quantify this both analytically and empirically. We show that imperfect linkage disequilibrium (LD) betwe...

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Publication status:
Published

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Publisher copy:
10.1002/gepi.20576

Authors


Journal:
Genetic epidemiology
Volume:
35
Issue:
4
Pages:
278-290
Publication date:
2011-05-01
DOI:
EISSN:
1098-2272
ISSN:
0741-0395
Source identifiers:
127157
Language:
English
Keywords:
Pubs id:
pubs:127157
UUID:
uuid:43fe2008-cfda-429f-a08b-89085a1acb99
Local pid:
pubs:127157
Deposit date:
2012-12-19

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