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Regulation of immune response by Plasmodium-infected red blood cells.

Abstract:

During the asexual blood stage infection of the human malaria parasite, Plasmodium falciparum, parasite-derived proteins are inserted onto the surface of the host red blood cell membrane. These proteins are highly variable and were originally thought only to mediate antigenic variation, and sequestration of parasites from peripheral circulation, thus enabling immune evasion. Recent studies have revealed that PfEMP-1 and other molecules on the P. falciparum-infected red blood cell (PfRBC) acti...

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Publication status:
Published

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Authors


Ndungu, FM More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Tropical Medicine
Langhorne, J More by this author
Journal:
Parasite immunology
Volume:
27
Issue:
10-11
Pages:
373-384
Publication date:
2005
DOI:
EISSN:
1365-3024
ISSN:
0141-9838
URN:
uuid:43f9beb8-d678-4038-8348-16cc25d4887f
Source identifiers:
39647
Local pid:
pubs:39647

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