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Pregnancy outcomes after first-trimester treatment with artemisinin derivatives versus non-artemisinin antimalarials: a systematic review and individual patient data meta-analysis

Abstract:
Background
Malaria in the first trimester of pregnancy is associated with adverse pregnancy outcomes. Artemisinin-based combination therapies (ACTs) are a highly effective, first-line treatment for uncomplicated Plasmodium falciparum malaria, except in the first trimester of pregnancy, when quinine with clindamycin is recommended due to concerns about the potential embryotoxicity of artemisinins. We compared adverse pregnancy outcomes after artemisinin-based treatment (AB... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1016/s0140-6736(22)01881-5

Authors


Publisher:
Elsevier
Journal:
The Lancet More from this journal
Volume:
401
Issue:
10371
Pages:
118-130
Place of publication:
England
Publication date:
2022-11-25
Acceptance date:
2022-09-22
DOI:
EISSN:
1474-547X
ISSN:
0140-6736
Pmid:
36442488
Language:
English
Keywords:
Pubs id:
1312368
Local pid:
pubs:1312368
Deposit date:
2023-01-09

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