Journal article
Adjuvant effects elicited by novel oligosaccharide variants of detoxified meningococcal lipopolysaccharides on neisseria meningitidis recombinant porA protein: a comparison in mice
- Abstract:
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Neisseria meningitidis lipopolysaccharide (LPS) has adjuvant properties that can be exploited to assist vaccine immunogenicity. The modified penta-acylated LPS retains the adjuvant properties of hexa-acylated LPS but has a reduced toxicity profile. In this study we investigated whether two modified glycoform structures (LgtE and IcsB) of detoxified penta-acylated LPS exhibited differential adjuvant properties when formulated as native outer membrane vesicles (nOMVs) as compared to the previou...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 1.7MB, Terms of use)
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- Publisher copy:
- 10.1371/journal.pone.0115713
Authors
Bibliographic Details
- Publisher:
- Public Library of Science
- Journal:
- PLoS ONE More from this journal
- Volume:
- 9
- Issue:
- 12
- Pages:
- ARTN e115713
- Publication date:
- 2014-12-29
- Acceptance date:
- 2014-11-30
- DOI:
- EISSN:
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1932-6203
Item Description
- Language:
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English
- Keywords:
- UUID:
-
uuid:43ee50fd-9266-4e15-86e3-bbaffe0cd60f
- Local pid:
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pubs:501663
- Source identifiers:
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501663
- Deposit date:
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2015-01-16
Terms of use
- Copyright holder:
- Mehta et al
- Copyright date:
- 2014
- Notes:
- Copyright: © 2014 Mehta et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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