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Regulation of the stem cell leukemia (SCL) gene: a tale of two fishes.

Abstract:

The stem cell leukemia (SCL) gene encodes a tissue-specific basic helix-loop-helix (bHLH) protein with a pivotal role in hemopoiesis and vasculogenesis. Several enhancers have been identified within the murine SCL locus that direct reporter gene expression to subdomains of the normal SCL expression pattern, and long-range sequence comparisons of the human and murine SCL loci have identified additional candidate enhancers. To facilitate the characterization of regulatory elements, we have sequ...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.101532998

Authors


Barton, LM More by this author
Gottgens, B More by this author
Gilbert, JG More by this author
Grafham, D More by this author
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
98
Issue:
12
Pages:
6747-6752
Publication date:
2001-06-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:43d587f0-cd60-4c43-bcaf-35d301dcfe56
Source identifiers:
106324
Local pid:
pubs:106324

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