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A chemokine-dependent stromal induction mechanism for aberrant lymphocyte accumulation and compromised lymphatic return in rheumatoid arthritis.

Abstract:

According to the current model for tissue-specific homing, specificity is conferred by the selective recruitment of lymphocyte populations from peripheral blood, based on their expression of chemokine and adhesion receptors (endothelial selection). In this study, we provide evidence for an alternative stromal induction mechanism that operates in chronic inflammation. We show that the human rheumatoid synovial microenvironment directly induces functional inflammatory (CCR5 and CXCR3) and const...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.174.3.1693

Authors


Haworth, O More by this author
Hardie, DL More by this author
Siewert, C More by this author
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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
174
Issue:
3
Pages:
1693-1700
Publication date:
2005-02-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:43c6c00a-4eb8-46e7-af7d-dcbcf2899520
Source identifiers:
102735
Local pid:
pubs:102735

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