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Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria.

Abstract:

There is an urgent need for new antimalarial drugs with novel mechanisms of action to deliver effective control and eradication programs. Parasite resistance to all existing antimalarial classes, including the artemisinins, has been reported during their clinical use. A failure to generate new antimalarials with novel mechanisms of action that circumvent the current resistance challenges will contribute to a resurgence in the disease which would represent a global health emergency. Here we pr...

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Publisher copy:
10.1073/pnas.1205651109

Authors


Biagini, GA More by this author
Mubaraki, MA More by this author
Srivastava, A More by this author
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
109
Issue:
21
Pages:
8298-8303
Publication date:
2012-05-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:43c631ea-aebd-4ae3-9c91-a1ace05ed68b
Source identifiers:
329113
Local pid:
pubs:329113

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