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A genome-wide association study of IVGTT-based measures of first phase insulin secretion refines the underlying physiology of Type 2 Diabetes variants.

Abstract:

Understanding the physiological mechanisms by which common variants predispose to type 2 diabetes requires large studies with detailed measures of insulin secretion and sensitivity. Here we performed the largest genome-wide association study of first phase insulin secretion, as measured by intravenous glucose tolerance tests, using up to 5,567 non-diabetic individuals from 10 studies. We aimed to refine the mechanisms of 178 known associations between common variants and glycaemic traits a...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.2337/db16-1452

Authors


Jonsson, A More by this author
Jackson, AU More by this author
van Leewen, N More by this author
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Grant:
SZ-245 50371-GLUCOSEGENES-FP7-IDEAS-ERC
European Federation of Pharmaceutical Industries and Associations More from this funder
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Publisher:
American Diabetes Association Publisher's website
Journal:
Diabetes Journal website
Publication date:
2017-05-05
DOI:
EISSN:
1939-327X
ISSN:
0012-1797
Pubs id:
pubs:695826
URN:
uri:43c4e279-7587-49fe-93d3-d736b91add4e
UUID:
uuid:43c4e279-7587-49fe-93d3-d736b91add4e
Local pid:
pubs:695826
Language:
English
Keywords:

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