Understanding the physiological mechanisms by which common variants predispose to type 2 diabetes requires large studies with detailed measures of insulin secretion and sensitivity. Here we performed the largest genome-wide association study of first phase insulin secretion, as measured by intravenous glucose tolerance tests, using up to 5,567 non-diabetic individuals from 10 studies. We aimed to refine the mechanisms of 178 known associations between common variants and glycaemic traits a...Expand abstract
- Publication status:
- Peer review status:
- Peer reviewed
- Accepted manuscript
- NWO 184.021.007
- Copyright holder:
- American Diabetes Association
- Copyright date:
- © 2017 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at http://www.diabetesjournals.org/content/license.
A genome-wide association study of IVGTT-based measures of first phase insulin secretion refines the underlying physiology of Type 2 Diabetes variants.
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