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Journal article

Increased substitution rates surrounding low-complexity regions within primate proteins.

Abstract:

Previous studies have found that DNA-flanking low-complexity regions (LCRs) have an increased substitution rate. Here, the substitution rate was confirmed to increase in the vicinity of LCRs in several primate species, including humans. This effect was also found among human sequences from the 1000 Genomes Project. A strong correlation was found between average substitution rate per site and distance from the LCR, as well as the proportion of genes with gaps in the alignment at each site and ...

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Publication status:
Published

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Publisher copy:
10.1093/gbe/evu042

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
Publisher:
Oxford University Press
Journal:
Genome biology and evolution
Volume:
6
Issue:
3
Pages:
655-665
Publication date:
2014-03-05
DOI:
EISSN:
1759-6653
ISSN:
1759-6653
URN:
uuid:43c45803-f95f-422c-a3f1-fa7439d66b21
Source identifiers:
450948
Local pid:
pubs:450948

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