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Journal article

Myocardial energy shortage and unmet anaplerotic needs in the fasted long-chain acyl-CoA dehydrogenase knockout mouse.

Abstract:

AIMS: The aim of this animal study is to assess fasting-induced changes in myocardial substrate metabolism and energy status as a consequence of mitochondrial long-chain fatty acid β-oxidation deficiency, using magnetic resonance spectroscopy (MRS). METHODS AND RESULTS: Carbon-13 ((13)C) MRS of hyperpolarized [1-(13)C]pyruvate was used to assess in vivo pyruvate dehydrogenase (PDH) activity in fed and fasted wild-type (WT) mice and long-chain acyl-CoA dehydrogenase knockout (LCAD KO) mice. PD...

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Publication status:
Published

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Publisher copy:
10.1093/cvr/cvt212

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics, BHF Centre of Research Excellence
Role:
Author
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Journal:
Cardiovascular research
Volume:
100
Issue:
3
Pages:
441-449
Publication date:
2013-12-05
DOI:
EISSN:
1755-3245
ISSN:
0008-6363
URN:
uuid:43c0db20-d63b-4437-a4d7-e98d7b6cd085
Source identifiers:
429207
Local pid:
pubs:429207

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