- Abstract:
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Deubiquitinating enzymes (DUBs) constitute a diverse protein family. The specificities and functions of the majority of DUBs are unknown, although their impact on many biological and pathological processes is widely appreciated. This dissertation entails a detailed characterization of otubain 1 (OTUB1), an ovarian tumor domain-containing DUB. The presented work describes OTUB1’s specificity, localization, protein interactions, importance in infection with Yersinia, and proposes a novel mod...
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- Publication date:
- 2010
- Type of award:
- DPhil
- Level of award:
- Doctoral
- URN:
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uuid:43897bb0-9b24-4876-b67f-bc9ba70d28af
- Local pid:
- ora:5306
- Language:
- English
- Keywords:
- Subjects:
- Copyright holder:
- Mariola J. Edelmann
- Copyright date:
- 2010
- Notes:
- Only the front matter and chapter 1 of this thesis are currently available in ORA.
Thesis
Biochemical characterization of a novel deubiquitinating enzyme otubain 1 and investigation into its role in Yersinia infection
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