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Thesis

Biochemical characterization of a novel deubiquitinating enzyme otubain 1 and investigation into its role in Yersinia infection

Abstract:

Deubiquitinating enzymes (DUBs) constitute a diverse protein family. The specificities and functions of the majority of DUBs are unknown, although their impact on many biological and pathological processes is widely appreciated. This dissertation entails a detailed characterization of otubain 1 (OTUB1), an ovarian tumor domain-containing DUB. The presented work describes OTUB1’s specificity, localization, protein interactions, importance in infection with Yersinia, and proposes a novel mod...

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Institution:
University of Oxford
Oxford college:
Jesus College
Department:
Medical Sciences Division - Clinical Medicine,Nuffield Department of - Centre for Cellular and Molecular Physiology

Contributors

Role:
Supervisor
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Funding agency for:
Mariola Jadwiga Edelmann
Publication date:
2010
Type of award:
DPhil
Level of award:
Doctoral
URN:
uuid:43897bb0-9b24-4876-b67f-bc9ba70d28af
Local pid:
ora:5306

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