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DNM3 and genetic modifiers of age of onset in LRRK2 Gly2019Ser parkinsonism: a genome-wide linkage and association study

Abstract:

Background

Leucine-rich repeat kinase 2 (LRRK2) mutation 6055G→A (Gly2019Ser) accounts for roughly 1% of patients with Parkinson’s disease in white populations, 13–30% in Ashkenazi Jewish populations, and 30–40% in North African Arab-Berber populations, although age of onset is variable. Some carriers have early-onset parkinsonism, whereas others remain asymptomatic despite advanced age. We aimed to use a genome-wide approach to identify genetic variability that directly aff ects...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1016/S1474-4422(16)30203-4

Authors


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Department:
Oxford, MSD, Clinical Neurosciences
Gustavsson, EK More by this author
Vilariño-Güell, C More by this author
Bortnick, S More by this author
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Leading Edge Endowment Fund More from this funder
National Institute on Aging More from this funder
National Institute of Neurological Disorders and Stroke More from this funder
Michael J Fox Foundation More from this funder
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Publisher:
Elsevier Publisher's website
Journal:
Lancet Neurology Journal website
Volume:
15
Issue:
12
Pages:
1248–1256
Publication date:
2016-09-05
Acceptance date:
2016-09-28
DOI:
ISSN:
1474-4465
Pubs id:
pubs:648553
URN:
uri:43892804-f6f5-4a06-8cb2-923986d68529
UUID:
uuid:43892804-f6f5-4a06-8cb2-923986d68529
Local pid:
pubs:648553

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