Journal article
Glycosphingolipid depletion in PC12 cells using iminosugars protects neuronal membranes from anti-ganglioside antibody mediated injury.
- Abstract:
-
Autoimmune neuropathies are frequently associated with pathogenic anti-ganglioside antibodies targeting ganglioside-rich neuronal and glial membranes. The extent of injury is determined by the concentration of membrane ganglioside and thus reduction might be expected to attenuate disease. In this study, we suppressed ganglioside biosynthesis in PC12 cells with the glucosylceramide synthase inhibitor, N-butyldeoxynojirimycin and observed reduced plasma membrane antibody binding and a major neu...
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- Publication status:
- Published
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- Publisher copy:
- 10.1016/j.jneuroim.2008.06.033
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Authors
Bibliographic Details
- Journal:
- Journal of neuroimmunology
- Volume:
- 203
- Issue:
- 1
- Pages:
- 33-38
- Publication date:
- 2008-10-01
- DOI:
- EISSN:
-
1872-8421
- ISSN:
-
0165-5728
- Source identifiers:
-
185285
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:185285
- UUID:
-
uuid:4376fe4c-475f-459b-b9f6-b81bf96c05d9
- Local pid:
- pubs:185285
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2008
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