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Journal article

Glycosphingolipid depletion in PC12 cells using iminosugars protects neuronal membranes from anti-ganglioside antibody mediated injury.

Abstract:

Autoimmune neuropathies are frequently associated with pathogenic anti-ganglioside antibodies targeting ganglioside-rich neuronal and glial membranes. The extent of injury is determined by the concentration of membrane ganglioside and thus reduction might be expected to attenuate disease. In this study, we suppressed ganglioside biosynthesis in PC12 cells with the glucosylceramide synthase inhibitor, N-butyldeoxynojirimycin and observed reduced plasma membrane antibody binding and a major neu...

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Publication status:
Published

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Journal:
Journal of neuroimmunology
Volume:
203
Issue:
1
Pages:
33-38
Publication date:
2008-10-05
DOI:
EISSN:
1872-8421
ISSN:
0165-5728
URN:
uuid:4376fe4c-475f-459b-b9f6-b81bf96c05d9
Source identifiers:
185285
Local pid:
pubs:185285

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