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Rescue of dysfunctional autophagy attenuates hyperinflammatory responses from cystic fibrosis cells.

Abstract:

A hallmark feature of cystic fibrosis (CF) is progressive pulmonary obstruction arising from exaggerated host proinflammatory responses to chronic bacterial airway colonization. The mechanisms for these heightened inflammatory responses have been only partially characterized, hampering development of effective anti-inflammatory therapies. The aim of this study was to identify and validate novel dysfunctional processes or pathways driving the hyperinflammatory phenotype of CF cells using syste...

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Publisher copy:
10.4049/jimmunol.1201404

Authors


Blohmke, CJ More by this author
Falsafi, R More by this author
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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
190
Issue:
3
Pages:
1227-1238
Publication date:
2013-02-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:4373fe5d-da40-4afa-84af-50ffaf1d3c01
Source identifiers:
379910
Local pid:
pubs:379910

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