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Journal article

Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes.

Abstract:

Mutations in whole organisms are powerful ways of interrogating gene function in a realistic context. We describe a program, the Sanger Institute Mouse Genetics Project, that provides a step toward the aim of knocking out all genes and screening each line for a broad range of traits. We found that hitherto unpublished genes were as likely to reveal phenotypes as known genes, suggesting that novel genes represent a rich resource for investigating the molecular basis of disease. We found many u...

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Publication status:
Published

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Publisher copy:
10.1016/j.cell.2013.06.022

Authors


Journal:
Cell
Volume:
154
Issue:
2
Pages:
452-464
Publication date:
2013-07-01
DOI:
EISSN:
1097-4172
ISSN:
0092-8674
Source identifiers:
417424
Language:
English
Keywords:
Pubs id:
pubs:417424
UUID:
uuid:4367bbc4-4d47-452b-b769-beb63bbe86f0
Local pid:
pubs:417424
Deposit date:
2013-11-16

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