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PLCζ: A sperm-specific trigger of Ca2+ oscillations in eggs and embryo development

Abstract:

Upon fertilisation by sperm, mammalian eggs are activated by a series of intracellular Ca2+ oscillations that are essential for embryo development. The mechanism by which sperm induces this complex signalling phenomenon is unknown. One proposal is that the sperm introduces an exclusive cytosolic factor into the egg that elicits serial Ca2+ release. The 'sperm factor' hypothesis has not been ratified because a sperm-specific protein that generates repetitive Ca2+ transients and egg activation ...

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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Role:
Author
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Journal:
Development
Volume:
129
Issue:
15
Pages:
3533-3544
Publication date:
2002-08-05
ISSN:
0950-1991
URN:
uuid:435ffb6e-f070-4545-b801-5f60123179e6
Source identifiers:
185364
Local pid:
pubs:185364

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