Modeling stem/progenitor cell-induced neovascularization and oxygenation around solid implants.

Journal article

Tissue engineering constructs and other solid implants with biomedical applications, such as drug delivery devices or bioartificial organs, need oxygen (O(2)) to function properly. To understand better the vascular integration of such devices, we recently developed a novel model sensor containing O(2)-sensitive crystals, consisting of a polymeric capsule limited by a nanoporous filter. The sensor was implanted in mice with hydrogel alone (control) or hydrogel embedded with mouse CD117/c-kit+ ...

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Authors: Jain, H; Moldovan, N; Byrne, H

• Publication status: Published
• Publisher: Mary Ann Liebert Inc.
• Journal: Tissue engineering. Part C, Methods
• Volume: 18
• Issue: 7
• Pages: 487-495
• Publication date: 2012-07-01
• DOI: 10.1089/ten.tec.2011.0452
• EISSN: 1937-3392
• ISSN: 1937-3384
• Language: English
• Keywords: Hydrogel; Stem Cells; Neovascularization, Physiologic; Models, Theoretical; Oxygen; Cell Respiration; Computer Simulation; Implants, Experimental; Polymers; Animals; Tissue Engineering; Adipogenesis; Mice