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A synthetic diphosphoinositol phosphate analogue of inositol trisphosphate

Abstract:

Diphosphoinositol phosphates (PP-InsPs) are inositol phosphates (InsPs) that contain PP (diphosphate) groups. Converting a phosphate group in an InsP into a diphosphate has been reported to enhance affinity for some binding proteins. We synthesised 1-PP-Ins(4,5)P2, the first diphosphate analogue of the intracellular signalling molecule InsP3, and examined its effects on InsP3 receptors, which are intracellular Ca2+ channels. 1-PP-Ins(4,5)P2 was indistinguishable from InsP3 in its ability to b...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1039/C8MD00149A

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pharmacology
Unterlass, J More by this author
Konieczny, V More by this author
Taylor, CW More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pharmacology
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Funding agency for:
Taylor, CW
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Funding agency for:
Potter, BVL
Swedish Pain Relief Foundation More from this funder
Swedish Cancer Society More from this funder
Publisher:
Royal Society of Chemistry Publisher's website
Journal:
MedChemComm Journal website
Volume:
9
Issue:
17
Pages:
1105-1113
Publication date:
2018-06-04
Acceptance date:
2018-04-22
DOI:
EISSN:
2040-2511
ISSN:
2040-2503
Pubs id:
pubs:843802
URN:
uri:434ca48f-72f0-4d7b-a407-8d68ec74e976
UUID:
uuid:434ca48f-72f0-4d7b-a407-8d68ec74e976
Local pid:
pubs:843802

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