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Dopaminergic neurons promote hippocampal reactivation and spatial memory persistence.

Abstract:
We found that optogenetic burst stimulation of hippocampal dopaminergic fibers from midbrain neurons in mice exploring novel environments enhanced the reactivation of pyramidal cell assemblies during subsequent sleep/rest. When applied during spatial learning of new goal locations, dopaminergic photostimulation improved the later recall of neural representations of space and stabilized memory performance. These findings reveal that midbrain dopaminergic neurons promote hippocampal network dynamics associated with memory persistence.
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1038/nn.3843

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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology, BNDU
Role:
Author
Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Neuroscience Journal website
Volume:
17
Issue:
12
Pages:
1658-1660
Publication date:
2014-12-05
DOI:
EISSN:
1546-1726
ISSN:
1097-6256
URN:
uuid:4344bf18-94bc-4acf-95a5-0d4b8135a498
Source identifiers:
487364
Local pid:
pubs:487364

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