Journal article
Dopaminergic neurons promote hippocampal reactivation and spatial memory persistence.
- Abstract:
- We found that optogenetic burst stimulation of hippocampal dopaminergic fibers from midbrain neurons in mice exploring novel environments enhanced the reactivation of pyramidal cell assemblies during subsequent sleep/rest. When applied during spatial learning of new goal locations, dopaminergic photostimulation improved the later recall of neural representations of space and stabilized memory performance. These findings reveal that midbrain dopaminergic neurons promote hippocampal network dynamics associated with memory persistence.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Accepted manuscript, pdf, 1.2MB)
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- Publisher copy:
- 10.1038/nn.3843
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Authors
Funding
Bibliographic Details
- Publisher:
- Nature Publishing Group Publisher's website
- Journal:
- Nature Neuroscience Journal website
- Volume:
- 17
- Issue:
- 12
- Pages:
- 1658-1660
- Publication date:
- 2014-12-01
- Acceptance date:
- 2014-09-23
- DOI:
- EISSN:
-
1546-1726
- ISSN:
-
1097-6256
- Source identifiers:
-
487364
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:487364
- UUID:
-
uuid:4344bf18-94bc-4acf-95a5-0d4b8135a498
- Local pid:
- pubs:487364
- Deposit date:
- 2016-03-08
Terms of use
- Copyright holder:
- Nature America
- Copyright date:
- 2014
- Notes:
- © 2014 Nature America, Inc. All rights reserved.
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