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Polymethylmethacrylate-induced inflammatory macrophages resorb bone.

Abstract:

Macrophages and their fused products are commonly found at the polymethylmethacrylate cement-bone interface, but it is not known if they contribute directly to the osteolysis associated with loosening of the cemented prosthesis. We isolated mononuclear phagocytes from granulomas formed by subcutaneous implantation of polymethylmethacrylate into mice and incubated them on bone slices in which they formed resorption lacunae after co-culture for seven to 14 days with both marrow stromal cells an...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Athanasou, NA More by this author
Journal:
The Journal of bone and joint surgery. British volume
Volume:
74
Issue:
5
Pages:
652-658
Publication date:
1992-09-05
ISSN:
0301-620X
URN:
uuid:43441ed7-198f-413d-891b-b7cead06e529
Source identifiers:
107668
Local pid:
pubs:107668

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