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Journal article

The role of tetrahydrobiopterin in inflammation and cardiovascular disease.

Abstract:

The cofactor tetrahydrobiopterin (BH4) is required for nitric oxide (NO) production by all nitric oxide synthase (NOS) enzymes and is a key regulator of cellular redox signalling. When BH4 levels become limiting NOS enzymes become 'uncoupled' and produce superoxide rather than NO. Endothelial cell BH4 is required for the maintenance of vascular function through NO production, and reduced BH4 levels are associated with vascular dysfunction. Evidence increasingly points to important roles for B...

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Publication status:
Published

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Publisher copy:
10.1160/th12-06-0424

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
Journal:
Thrombosis and haemostasis
Volume:
108
Issue:
5
Pages:
832-839
Publication date:
2012-11-01
DOI:
ISSN:
0340-6245
Source identifiers:
354004
Language:
English
Keywords:
Pubs id:
pubs:354004
UUID:
uuid:43423c50-fdb4-4957-a1fe-5ec195ff989b
Local pid:
pubs:354004
Deposit date:
2013-11-17

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