Journal article icon

Journal article

The role of tetrahydrobiopterin in inflammation and cardiovascular disease.

Abstract:

The cofactor tetrahydrobiopterin (BH4) is required for nitric oxide (NO) production by all nitric oxide synthase (NOS) enzymes and is a key regulator of cellular redox signalling. When BH4 levels become limiting NOS enzymes become 'uncoupled' and produce superoxide rather than NO. Endothelial cell BH4 is required for the maintenance of vascular function through NO production, and reduced BH4 levels are associated with vascular dysfunction. Evidence increasingly points to important roles for B...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1160/th12-06-0424

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Cardiovascular Medicine, BHF Centre of Research Excellence
Role:
Author
Journal:
Thrombosis and haemostasis
Volume:
108
Issue:
5
Pages:
832-839
Publication date:
2012-11-05
DOI:
ISSN:
0340-6245
URN:
uuid:43423c50-fdb4-4957-a1fe-5ec195ff989b
Source identifiers:
354004
Local pid:
pubs:354004

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP