The cofactor tetrahydrobiopterin (BH4) is required for nitric oxide (NO) production by all nitric oxide synthase (NOS) enzymes and is a key regulator of cellular redox signalling. When BH4 levels become limiting NOS enzymes become 'uncoupled' and produce superoxide rather than NO. Endothelial cell BH4 is required for the maintenance of vascular function through NO production, and reduced BH4 levels are associated with vascular dysfunction. Evidence increasingly points to important roles for B...Expand abstract
- Publication status:
- Publisher copy:
- Copyright date:
The role of tetrahydrobiopterin in inflammation and cardiovascular disease.
Views and Downloads
If you are the owner of this record, you can report an update to it here: Report update to this record