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The effect of a met-enkephalin analogue on growth hormone, prolactin, gonadotropins, cortisol and thyroid stimulating hormone in healthy elderly men.

Abstract:

The aim of the study was to evaluate the effect of the guanyl derivative of the opioid analogue D-ala2,MePhe4-Met-enkephalin-(o)-ol (G-DAMME) on pituitary secretion in healthy elderly men. Nine healthy elderly men (65-88 years) and 10 young adults (20-30 years) were studied. GH, PRL, gonadotropins, cortisol (to evaluate the effect on ACTH) and TSH were measured after G-DAMME (0.25 mg iv) or placebo administration. In elderly men, the GH response to G-DAMME was reduced or absent, while prompt ...

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Publication status:
Published

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Authors


Delitala, G More by this author
Sessarego, P More by this author
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Journal:
Acta endocrinologica
Volume:
127
Issue:
3
Pages:
205-209
Publication date:
1992-09-05
ISSN:
0001-5598
URN:
uuid:4341880f-b58f-4fe0-89c4-1c1a1529c457
Source identifiers:
138640
Local pid:
pubs:138640

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