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Journal article

Structure of HLA-A*0301 in complex with a peptide of proteolipid protein: insights into the role of HLA-A alleles in susceptibility to multiple sclerosis.

Abstract:

The structure of the human major histocompatability (MHC) class I molecule HLA-A*0301 (HLA-A3) in complex with a nonameric peptide (KLIETYFSK) has been determined by X-ray crystallography to 2.7 Å resolution. HLA-A3 is a predisposing allele for multiple sclerosis (MS), an autoimmune disease of the central nervous system. The KLIETYFSK peptide is a naturally processed epitope of proteolipid protein, a myelin protein and candidate target for immune-mediated myelin destruction in MS. Comparison ...

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Publication status:
Published

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Publisher copy:
10.1107/s0907444911007888

Authors


McMahon, RM More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Biology
Friese, MA More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience, Molecular Medicine
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Journal:
Acta crystallographica. Section D, Biological crystallography
Volume:
67
Issue:
Pt 5
Pages:
447-454
Publication date:
2011-05-05
DOI:
EISSN:
1399-0047
ISSN:
0907-4449
URN:
uuid:433a31eb-7606-43fd-9008-e229a5672b0d
Source identifiers:
138825
Local pid:
pubs:138825

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