- Abstract:
-
Exhausted T cells express multiple co-inhibitory molecules that impair their function and limit immunity to chronic viral infection. Defining novel markers of exhaustion is important both for identifying and potentially reversing T cell exhaustion. Herein, we show that the ectonucleotidse CD39 is a marker of exhausted CD8+ T cells. CD8+ T cells specific for HCV or HIV express high levels of CD39, but those specific for EBV and CMV do not. CD39 expressed by CD8+ T cells in chronic infection is...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 2.2MB)
-
- Publisher copy:
- 10.1371/journal.ppat.1005177
-
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- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PLoS Pathogens Journal website
- Volume:
- 11
- Issue:
- 10
- Pages:
- e1005177
- Chapter number:
- ARTN e1005177
- Publication date:
- 2015-10-20
- DOI:
- EISSN:
-
1553-7374
- ISSN:
-
1553-7366
- URN:
-
uuid:432f6320-bd49-406a-be0f-a3cea24c20de
- Source identifiers:
-
575121
- Local pid:
- pubs:575121
- Language:
- English
- Copyright holder:
- Gupta et al.
- Copyright date:
- 2015
- Notes:
- : © 2015 Gupta et al. This is an open access article distributed under the terms of the Creative Commons Attribution License. This is the publisher's version of the article. The final version is available online from the Public Library of Science at: [10.1371/journal.ppat.1005177]
Journal article
CD39 Expression identifies terminally exhausted CD8+ T cells
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