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Journal article

Metalloproteinase binding proteins: WO2009097397.

Abstract:

MMPs are a group of metalloendopeptidases whose major role is in extracellular matrix (ECM) catabolism under physiological and pathological conditions. ECM catabolism is often associated with different diseases, and accumulated studies support the causal relationship between MMPs and different diseases especially with cancer and arthritis. Therefore, MMPs have been considered as therapeutic target molecules. However, multiple failures of MMP inhibitor drugs in clinical trials from late 1990s ...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
Journal:
Expert opinion on therapeutic patents
Volume:
20
Issue:
8
Pages:
1091-1095
Publication date:
2010-08-01
DOI:
EISSN:
1744-7674
ISSN:
1354-3776
Source identifiers:
223989
Language:
English
Keywords:
Pubs id:
pubs:223989
UUID:
uuid:432ab6df-15a9-4d1d-b84a-7cdfcb10e81c
Local pid:
pubs:223989
Deposit date:
2012-12-19

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