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Journal article

Novel binding partners of Ldb1 are required for haematopoietic development.

Abstract:

Ldb1, a ubiquitously expressed LIM domain binding protein, is essential in a number of tissues during development. It interacts with Gata1, Tal1, E2A and Lmo2 to form a transcription factor complex regulating late erythroid genes. We identify a number of novel Ldb1 interacting proteins in erythroleukaemic cells, in particular the repressor protein Eto-2 (and its family member Mtgr1), the cyclin-dependent kinase Cdk9, and the bridging factor Lmo4. MO-mediated knockdowns in zebrafish show these...

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Publication status:
Published

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Publisher copy:
10.1242/dev.02656

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Journal:
Development (Cambridge, England)
Volume:
133
Issue:
24
Pages:
4913-4923
Publication date:
2006-12-05
DOI:
EISSN:
1477-9129
ISSN:
0950-1991
URN:
uuid:43270ca3-3a93-4cbd-a9be-9f2e5c50e8a7
Source identifiers:
106179
Local pid:
pubs:106179

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