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Tyrosine kinase c-Abl couples RNA polymerase II transcription to DNA double-strand breaks

Abstract:

DNA is constantly exposed to endogenous and exogenous damage. Various types of DNA repair counteract highly toxic DNA double-strand breaks (DSBs) to maintain genome stability. Recent findings suggest that the human DNA damage response (DDR) utilizes small RNA species, which are produced as long non-coding (nc)RNA precursors and promote recognition of DSBs. However, regulatory principles that control production of such transcripts remain largely elusive. Here we show that the Abelson tyrosine ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1093/nar/gkz024

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More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Role:
Author
ORCID:
0000-0003-0587-9782
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Role:
Author
Publisher:
Oxford University Press Publisher's website
Journal:
Nucleic Acids Research Journal website
Volume:
47
Issue:
7
Pages:
3467–3484
Publication date:
2019-01-22
Acceptance date:
2019-01-09
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
Pubs id:
pubs:958840
URN:
uri:4322b409-db7e-4c0a-9477-6a762ff3e54b
UUID:
uuid:4322b409-db7e-4c0a-9477-6a762ff3e54b
Local pid:
pubs:958840

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