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Journal article

Impact of arsenite and its methylated metabolites on PARP-1 activity, PARP-1 gene expression and poly(ADP-ribosyl)ation in cultured human cells.

Abstract:

The underlying mechanisms of arsenic carcinogenicity are still not fully understood. Mechanisms currently discussed include the induction of oxidative DNA damage and the interference with DNA repair pathways. Still unclear is the role of biomethylation, which has long been considered to be one major detoxification process. Methylated arsenicals have recently been shown to interfere with DNA repair in cellular and subcellular systems, but up to now no DNA repair protein has been identified bei...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Role:
Author
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Journal:
DNA repair
Volume:
6
Issue:
1
Pages:
61-70
Publication date:
2007-01-05
DOI:
EISSN:
1568-7856
ISSN:
1568-7864
URN:
uuid:431af496-c78c-4622-b4b0-60bb949c9b31
Source identifiers:
130840
Local pid:
pubs:130840

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