Journal article
Impact of arsenite and its methylated metabolites on PARP-1 activity, PARP-1 gene expression and poly(ADP-ribosyl)ation in cultured human cells.
- Abstract:
-
The underlying mechanisms of arsenic carcinogenicity are still not fully understood. Mechanisms currently discussed include the induction of oxidative DNA damage and the interference with DNA repair pathways. Still unclear is the role of biomethylation, which has long been considered to be one major detoxification process. Methylated arsenicals have recently been shown to interfere with DNA repair in cellular and subcellular systems, but up to now no DNA repair protein has been identified bei...
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- Publication status:
- Published
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- Publisher copy:
- 10.1016/j.dnarep.2006.08.008
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Bibliographic Details
- Journal:
- DNA repair
- Volume:
- 6
- Issue:
- 1
- Pages:
- 61-70
- Publication date:
- 2007-01-01
- DOI:
- EISSN:
-
1568-7856
- ISSN:
-
1568-7864
- Source identifiers:
-
130840
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:130840
- UUID:
-
uuid:431af496-c78c-4622-b4b0-60bb949c9b31
- Local pid:
- pubs:130840
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2007
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