Journal article icon

Journal article

Mefloquine pharmacokinetics and resistance in children with acute falciparum malaria.

Abstract:

The pharmacokinetic properties of mefloquine hydrochloride (15 mg base kg -1) were studied in 12 Karen children (five girls, seven boys) aged between 5 and 10 years presenting with uncomplicated falciparum malaria. The drug was well tolerated. Mean (s.d.) peak blood drug concentrations of 2031 (831) ng ml-1 were reached in a median of 8 (range 6-24) h. Mean (s.d.) estimates for oral clearance and mean residence time were 0.52 (0.27) ml min -1 kg -1 and 15.3 (4.7) days, respectively. These val...

Expand abstract

Actions


Access Document


Authors


ter Kuile, F More by this author
Chongsuphajaisiddhi, T More by this author
Na Bangchang, K More by this author
Karbwang, J More by this author
Expand authors...
Journal:
British journal of clinical pharmacology
Volume:
31
Issue:
5
Pages:
556-559
Publication date:
1991-05-05
DOI:
EISSN:
1365-2125
ISSN:
0306-5251
URN:
uuid:4315da22-41c8-48ca-aef9-e700e38fd957
Source identifiers:
8705
Local pid:
pubs:8705

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP