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Delayed cerebral ischaemia after subarachnoid haemorrhage: looking beyond vasospasm.

Abstract:

Despite improvements in the clinical management of aneurysmal subarachnoid haemorrhage over the last decade, delayed cerebral ischaemia (DCI) remains the single most important cause of morbidity and mortality in those patients who survive the initial bleed. The pathological mechanisms underlying DCI are still unclear and the calcium channel blocker nimodipine remains the only therapeutic intervention proven to improve functional outcomes after SAH. The recent failure of the drug clazosentan t...

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Publication status:
Published

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Publisher copy:
10.1093/bja/aes264

Authors


Rowland, MJ More by this author
Hadjipavlou, G More by this author
Westbrook, J More by this author
Pattinson, KT More by this author
Journal:
British journal of anaesthesia
Volume:
109
Issue:
3
Pages:
315-329
Publication date:
2012-09-05
DOI:
EISSN:
1471-6771
ISSN:
0007-0912
URN:
uuid:4313163c-1074-4f93-8484-361dc0547bdb
Source identifiers:
349949
Local pid:
pubs:349949

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