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Journal article

T cell receptor CDR2 beta and CDR3 beta loops collaborate functionally to shape the iNKT cell repertoire.

Abstract:

Mouse type I natural killer T cell receptors (iNKT TCRs) use a single V alpha 14-J alpha 18 sequence and V beta s that are almost always V beta 8.2, V beta 7, or V beta 2, although the basis of this differential usage is unclear. We showed that the V beta bias occurred as a consequence of the CDR2 beta loops determining the affinity of the iNKT TCR for CD1d-glycolipids, thus controlling positive selection. Within a conserved iNKT-TCR-CD1d docking framework, these inherent V beta-CD1d affiniti...

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Publication status:
Published

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Authors


Mallevaey, T More by this author
Scott-Browne, JP More by this author
Matsuda, JL More by this author
Pellicci, DG More by this author
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Journal:
Immunity
Volume:
31
Issue:
1
Pages:
60-71
Publication date:
2009-07-05
DOI:
EISSN:
1097-4180
ISSN:
1074-7613
URN:
uuid:430f3450-ba0a-4c85-8785-bc7dc53fdce5
Source identifiers:
34789
Local pid:
pubs:34789

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