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Normal development and function of T cells in proline rich 7 (Prr7) deficient mice

Abstract:

Transmembrane adaptor proteins (TRAPs) are important organisers for the transduction of immunoreceptor-mediated signals. Prr7 is a TRAP that regulates T cell receptor (TCR) signalling and potently induces cell death when overexpressed in human Jurkat T cells. Whether endogenous Prr7 has a similar functional role is currently unknown. To address this issue, we analysed the development and function of the immune system in Prr7 knockout mice. We found that loss of Prr7 partially impairs developm...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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10.1371/journal.pone.0162863

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Department:
Oxford, MSD, NDM, Oxford Ludwig Institute
Role:
Author
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS ONE Journal website
Volume:
11
Issue:
9
Pages:
Article: e0162863
Publication date:
2016-09-22
Acceptance date:
2016-08-30
DOI:
ISSN:
1932-6203
Pubs id:
pubs:646393
URN:
uri:430df82d-6d85-4654-b72f-ad59415b4d79
UUID:
uuid:430df82d-6d85-4654-b72f-ad59415b4d79
Local pid:
pubs:646393
Paper number:
9
Keywords:

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