- Abstract:
-
Transmembrane adaptor proteins (TRAPs) are important organisers for the transduction of immunoreceptor-mediated signals. Prr7 is a TRAP that regulates T cell receptor (TCR) signalling and potently induces cell death when overexpressed in human Jurkat T cells. Whether endogenous Prr7 has a similar functional role is currently unknown. To address this issue, we analysed the development and function of the immune system in Prr7 knockout mice. We found that loss of Prr7 partially impairs developm...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 2.2MB)
-
- Publisher copy:
- 10.1371/journal.pone.0162863
-
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- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PLoS ONE Journal website
- Volume:
- 11
- Issue:
- 9
- Pages:
- Article: e0162863
- Publication date:
- 2016-09-22
- Acceptance date:
- 2016-08-30
- DOI:
- ISSN:
-
1932-6203
- Pubs id:
-
pubs:646393
- URN:
-
uri:430df82d-6d85-4654-b72f-ad59415b4d79
- UUID:
-
uuid:430df82d-6d85-4654-b72f-ad59415b4d79
- Local pid:
- pubs:646393
- Paper number:
- 9
- Keywords:
- Copyright holder:
- Hrdinka et al.
- Copyright date:
- 2016
- Notes:
- Copyright © 2016 Hrdinka et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Journal article
Normal development and function of T cells in proline rich 7 (Prr7) deficient mice
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