- Abstract:
-
The impact of obesity on nitric oxide (NO)-mediated coronary microvascular responses is poorly understood. Thus NO-mediated vasomotor responses were investigated in pressurized coronary arterioles ( approximately 100 microm) isolated from lean (on normal diet) and obese (fed with 60% of saturated fat) rats. We found that dilations to acetylcholine (ACh) were not significantly different in obese and lean rats (lean, 83 +/- 4%; and obese, 85 +/- 3% at 1 microM), yet the inhibition of NO synthes...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1152/ajpheart.01198.2007
-
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- Journal:
- American journal of physiology. Heart and circulatory physiology
- Volume:
- 294
- Issue:
- 6
- Pages:
- H2558-H2564
- Publication date:
- 2008-06-05
- DOI:
- EISSN:
-
1522-1539
- ISSN:
-
0363-6135
- URN:
-
uuid:430df647-d997-4138-b0ed-3670d73189e6
- Source identifiers:
-
164517
- Local pid:
- pubs:164517
- Language:
- English
- Keywords:
- Copyright date:
- 2008
Journal article
High-fat diet-induced obesity leads to increased NO sensitivity of rat coronary arterioles: role of soluble guanylate cyclase activation.
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