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High-fat diet-induced obesity leads to increased NO sensitivity of rat coronary arterioles: role of soluble guanylate cyclase activation.

Abstract:

The impact of obesity on nitric oxide (NO)-mediated coronary microvascular responses is poorly understood. Thus NO-mediated vasomotor responses were investigated in pressurized coronary arterioles ( approximately 100 microm) isolated from lean (on normal diet) and obese (fed with 60% of saturated fat) rats. We found that dilations to acetylcholine (ACh) were not significantly different in obese and lean rats (lean, 83 +/- 4%; and obese, 85 +/- 3% at 1 microM), yet the inhibition of NO synthes...

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Publication status:
Published

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Publisher copy:
10.1152/ajpheart.01198.2007

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Journal:
American journal of physiology. Heart and circulatory physiology
Volume:
294
Issue:
6
Pages:
H2558-H2564
Publication date:
2008-06-05
DOI:
EISSN:
1522-1539
ISSN:
0363-6135
URN:
uuid:430df647-d997-4138-b0ed-3670d73189e6
Source identifiers:
164517
Local pid:
pubs:164517

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