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CXCR3-dependent recruitment and CCR6-mediated positioning of Th-17 cells in the inflamed liver

Abstract:

Background and Aims: IL-17 secreting CD4 (Th17) and CD8 (Tc17) T cells have been implicated in immune-mediated liver diseases, but the molecular basis for their recruitment and positioning within the liver is unknown. Methods: The phenotype and migratory behaviour of human liver-derived Th17 and Tc17 cells were investigated by flow cytometry and chemotaxis and flow-based adhesion assays. The recruitment of murine Th17 cells to the liver was studied in vivo using intra-vital microscopy. Result...

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Publisher copy:
10.1016/j.jhep.2012.07.008

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Journal:
Journal of Hepatology
Volume:
57
Issue:
5
Pages:
1044-1051
Publication date:
2012-11-05
DOI:
ISSN:
0168-8278
URN:
uuid:4302e616-2f02-490a-9f6e-39b7a0fdaef9
Source identifiers:
356604
Local pid:
pubs:356604

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