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Mechanism of SigR inhibition by the anti-sigma factor RsrA from Streptomyces coelicolor

Abstract:

The extracytoplasmic function (ECF) sigma factor SigR (σR) is a bacterial transcription factor involved in the regulation of cytosolic redox homeostasis in Streptomyces coelicolor. SigR activity is regulated by its cognate anti-sigma factor RsrA. RsrA is a member of the zinc-anti-sigma (ZAS) family, which in its reduced state binds a single Zn2+ ion coordinated by 3 cysteine residues and a histidine. RsrA senses oxidative stress within the cytosol and respond...

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Institution:
University of Oxford
Research group:
Professor Colin Kleanthous
Oxford college:
Hertford College
Department:
Medical Sciences Division - Biochemistry

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Role:
Supervisor
Publication date:
2015
Type of award:
MSc by Research
Level of award:
Masters
Awarding institution:
Oxford University, UK
URN:
uuid:42f3b4f3-1921-4402-baef-4c2e9babeeca
Local pid:
ora:10443

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