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Association of the tumour necrosis factor alpha -308 but not the interleukin 10 -627 promoter polymorphism with genetic susceptibility to primary sclerosing cholangitis.

Abstract:

BACKGROUND AND AIMS: Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease of unknown aetiology. Abnormalities in immune regulation and genetic associations suggest that PSC is an immune mediated disease. Several polymorphisms within the tumour necrosis factor alpha (TNF-alpha) and interleukin 10 (IL-10) promoter genes have been described which influence expression of these cytokines. This study examines the possible association between polymorphisms at the -308 and -62...

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Publication status:
Published

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Publisher copy:
10.1136/gut.49.2.288

Authors


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Journal:
Gut
Volume:
49
Issue:
2
Pages:
288-294
Publication date:
2001-08-05
DOI:
EISSN:
1468-3288
ISSN:
0017-5749
URN:
uuid:42f0faf7-0388-4656-ab2a-81d5b0d0689a
Source identifiers:
171752
Local pid:
pubs:171752

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