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Bilateral adaptive deep brain stimulation is effective in Parkinson's disease

Abstract:
Introduction and objectives: Adaptive deep brain stimulation (aDBS) uses feedback from brain signals to guide stimulation. A recent acute trial of unilateral aDBS showed that aDBS can lead to substantial improvements in contralateral hemibody Unified Parkinson’s Disease Rating Scale (UPDRS) motor scores and may be superior to conventional continuous DBS in Parkinson’s disease (PD). We test whether potential benefits are retained with bilateral aDBS and in the face of concurre... Expand abstract
Publication status:
In press
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1136/jnnp-2015-310972

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neurosciences, Biomedical Research Centre
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neurosciences
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neurosciences
Foltynie, T More by this author
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Medical Research Council More from this funder
Rosetrees Trust More from this funder
National Institute for Health Research Oxford Biomedical Research Centre More from this funder
Publisher:
BMJ Publishing Group Publisher's website
Journal:
Journal of Neurology, Neurosurgery and Psychiatry Journal website
Publication date:
2015
DOI:
EISSN:
1468-330X
ISSN:
0022-3050
URN:
uuid:42e97ff8-a7b2-4063-8b29-e992cf74aa13
Source identifiers:
574364
Local pid:
pubs:574364

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