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The importance of including local correlation times in the calculation of inter-proton distances from NMR measurements: ignoring local correlation times leads to significant errors in the conformational analysis of the Glc alpha1-2Glc alpha linkage by NMR spectroscopy.

Abstract:

The experimental determination of oligosaccharide conformations has traditionally used cross-linkage 1H-1H NOE/ROEs. As relatively few NOEs are observed, to provide sufficient conformational constraints this method relies on: accurate quantification of NOE intensities (positive constraints); analysis of absent NOEs (negative constraints); and hence calculation of inter-proton distances using the two-spin approximation. We have compared the results obtained by using 1H 2D NOESY, ROESY and T-RO...

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Publication status:
Published

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Publisher copy:
10.1039/b604126d

Authors


Mackeen, M More by this author
Cumpstey, I More by this author
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Journal:
Organic and biomolecular chemistry
Volume:
4
Issue:
11
Pages:
2241-2246
Publication date:
2006-06-05
DOI:
EISSN:
1477-0539
ISSN:
1477-0520
URN:
uuid:42e7757f-bf4b-49a7-b118-7879573cf0ea
Source identifiers:
99863
Local pid:
pubs:99863

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