Journal article icon

Journal article

Complement activation by immunoglobulin does not depend solely on C1q binding.

Abstract:

A matched set of rat chimeric antibodies has been studied for their ability to activate various key stages of the complement cascade. Rat IgM and IgG2b were efficient at all stages from C1q binding to cell lysis. However, for other isotypes, a direct correlation between C1q binding and cell lysis did not apply. IgG2a, which was only modestly efficient at C1q binding, was relatively more so for binding and activation of while C1, and was by far the most effective isotype after IgG2b and IgM fo...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1002/eji.1830200208

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
European journal of immunology
Volume:
20
Issue:
2
Pages:
277-281
Publication date:
1990-02-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:42e507f3-9799-4bf5-86e9-35ff698ef8ab
Source identifiers:
25937
Local pid:
pubs:25937

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP