- Abstract:
-
A matched set of rat chimeric antibodies has been studied for their ability to activate various key stages of the complement cascade. Rat IgM and IgG2b were efficient at all stages from C1q binding to cell lysis. However, for other isotypes, a direct correlation between C1q binding and cell lysis did not apply. IgG2a, which was only modestly efficient at C1q binding, was relatively more so for binding and activation of while C1, and was by far the most effective isotype after IgG2b and IgM fo...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1002/eji.1830200208
-
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- Journal:
- European journal of immunology
- Volume:
- 20
- Issue:
- 2
- Pages:
- 277-281
- Publication date:
- 1990-02-05
- DOI:
- EISSN:
-
1521-4141
- ISSN:
-
0014-2980
- URN:
-
uuid:42e507f3-9799-4bf5-86e9-35ff698ef8ab
- Source identifiers:
-
25937
- Local pid:
- pubs:25937
- Copyright date:
- 1990
Journal article
Complement activation by immunoglobulin does not depend solely on C1q binding.
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