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Cyclic imine nitro-Mannich/lactamization cascades: a direct stereoselective synthesis of multicyclic piperidinone derivatives.

Abstract:
An efficient nitro-Mannich/lactamization cascade of gamma-nitro esters with cyclic imines for the preparation of architecturally complex multicyclic piperidinone ring-containing structures has been developed. The reaction is broad in scope and stereoselective and may be coupled to an enantioselective nitroolefin Michael addition reaction as part of a highly enantio- and diastereoselective multicomponent process.
Publication status:
Published

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Publisher copy:
10.1021/ol801666w

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
Journal:
Organic letters
Volume:
10
Issue:
19
Pages:
4267-4270
Publication date:
2008-10-01
DOI:
EISSN:
1523-7052
ISSN:
1523-7060
Source identifiers:
34366
Language:
English
Keywords:
Pubs id:
pubs:34366
UUID:
uuid:42d262f0-ff89-431a-87fb-3ba37679ffff
Local pid:
pubs:34366
Deposit date:
2012-12-19

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