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Cyclic imine nitro-Mannich/lactamization cascades: a direct stereoselective synthesis of multicyclic piperidinone derivatives.

Abstract:
An efficient nitro-Mannich/lactamization cascade of gamma-nitro esters with cyclic imines for the preparation of architecturally complex multicyclic piperidinone ring-containing structures has been developed. The reaction is broad in scope and stereoselective and may be coupled to an enantioselective nitroolefin Michael addition reaction as part of a highly enantio- and diastereoselective multicomponent process.
Publication status:
Published

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Publisher copy:
10.1021/ol801666w

Authors


Jakubec, P More by this author
Helliwell, M More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Journal:
Organic letters
Volume:
10
Issue:
19
Pages:
4267-4270
Publication date:
2008-10-05
DOI:
EISSN:
1523-7052
ISSN:
1523-7060
URN:
uuid:42d262f0-ff89-431a-87fb-3ba37679ffff
Source identifiers:
34366
Local pid:
pubs:34366

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