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Discovery by the Epistasis Project of an epistatic interaction between the GSTM3 gene and the HHEX/IDE/KIF11 locus in the risk of Alzheimer's disease

Abstract:

Despite recent discoveries in the genetics of sporadic Alzheimer's disease, there remains substantial " hidden heritability." It is thought that some of this missing heritability may be because of gene-gene, i.e., epistatic, interactions. We examined potential epistasis between 110 candidate polymorphisms in 1757 cases of Alzheimer's disease and 6294 control subjects of the Epistasis Project, divided between a discovery and a replication dataset. We found an epistatic interaction, between rs7...

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Authors


Bullock, JM More by this author
Cortina-Borja, M More by this author
Turton, JC More by this author
Prince, JA More by this author
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Journal:
Neurobiology of Aging
Volume:
34
Issue:
4
Pages:
1309.e1-1309.e7
Publication date:
2013-04-01
DOI:
EISSN:
1558-1497
ISSN:
0197-4580
URN:
uuid:42c470d4-4d79-4517-a92a-9ba9bd1ce605
Source identifiers:
379588
Local pid:
pubs:379588

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