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Increased stability and breakdown of brain effective connectivity during slow-wave sleep: mechanistic insights from whole-brain computational modelling

Abstract:

Recent research has found that the human sleep cycle is characterised by changes in spatiotemporal patterns of brain activity. Yet, we are still missing a mechanistic explanation of the local neuronal dynamics underlying these changes. We used whole-brain computational modelling to study the differences in global brain functional connectivity and synchrony of fMRI activity in healthy humans during wakefulness and slow-wave sleep. We applied a whole-brain model based on the normal form of a su...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/s41598-017-04522-x

Authors


Hindriks, R More by this author
Tagliazucchi, E More by this author
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Funding agency for:
Jobst, BM
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Funding agency for:
Jobst, BM
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Scientific Reports Journal website
Volume:
7
Issue:
4634
Pages:
1-16
Publication date:
2017-06-05
Acceptance date:
2017-05-16
DOI:
ISSN:
2045-2322
Pubs id:
pubs:707698
URN:
uri:42af751e-54de-4e10-bcfa-ecea8e1c315f
UUID:
uuid:42af751e-54de-4e10-bcfa-ecea8e1c315f
Local pid:
pubs:707698
Language:
English
Keywords:

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