Recognition of viral antigens at the cell surface.

Conference item

There is now a very good understanding of the way in which epitope peptides are generated from virus proteins and how the peptides bind to the class I MHC molecules. This gives a framework in which to analyse the potentially protective cytotoxic T lymphocyte response in human immunodeficiency virus infection. A detailed understanding of the specificity of the responding T cells, the clonality of these T cells and the effects of virus variation on the CTL gives a possible explanation for the u...

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Authors: McMichael, A; Klenerman, P; Rowland-Jones, S; Gotch, F; Moss, P

• Publication status: Published
• Journal: Cancer surveys
• Volume: 22
• Pages: 51-62
• Publication date: 1995-01-01
• Event title: Symposium on The Lymphocyte Cell Surface
• ISSN: 0261-2429
• Keywords: Antigens, Viral; Humans; Acquired Immunodeficiency Syndrome; Epitopes; Histocompatibility Antigens Class I; Peptides; T-Lymphocytes, Cytotoxic