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Journal article

Sub-pyrogenic systemic inflammation impacts on brain and behavior, independent of cytokines.

Abstract:

Systemic inflammation impacts on the brain and gives rise to behavioral changes, often referred to as 'sickness behavior'. These symptoms are thought to be mainly mediated by pro-inflammatory cytokines. We have investigated the communication pathways between the immune system and brain following sub-pyrogenic inflammation. Low grade systemic inflammation was induced in mice using lipopolysaccharide (LPS); 1-100 microg/kg to mimic aspects of bacterial infection. Changes in fever, open-field ac...

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Publication status:
Published

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Publisher copy:
10.1016/j.bbi.2007.01.012

Authors


Teeling, JL More by this author
Felton, LM More by this author
Deacon, RM More by this author
Cunningham, C More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Experimental Psychology
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Journal:
Brain, behavior, and immunity
Volume:
21
Issue:
6
Pages:
836-850
Publication date:
2007-08-05
DOI:
EISSN:
1090-2139
ISSN:
0889-1591
URN:
uuid:42ac5912-7422-4406-b99c-0c09042b9f11
Source identifiers:
310861
Local pid:
pubs:310861

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