Journal article
The genomic characterization of Salmonella Paratyphi A from an outbreak of enteric fever in Vadodara, India
- Abstract:
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Salmonella enterica Typhi (S. Typhi) and Paratyphi A (S. Paratyphi A) are the causative agents of enteric fever, a systemic human disease with a burden of 300 000 cases per year in India. The majority of enteric fever cases are associated with S. Typhi, resulting in a paucity of data regarding S. Paratyphi A, specifically with respect to genomic surveillance and antimicrobial resistance (AMR). Here, we exploited whole-genome sequencing (WGS) to identify S. Paratyphi A genotypes and AMR determinants associated with an outbreak of S. Paratyphi A in Vadodara, India, from December 2018 to December 2019. In total 117 S. Paratyphi A were isolated and genome sequenced, most were genotype 2.4.2 (72.6 % of all cases), which is the globally dominant genotype. The remainder were genotype 2.3 (25.6 %), while only two isolates belonged to genotype 2.4.1. A single base-pair mutation in gyrA, associated with reduced susceptibility to fluoroquinolones, was present in all of the outbreak isolates; with 74.35 % of isolates having a S83F substitution and the remainder having an S83Y substitution. Our surveillance study suggests that S. Paratyphi A is an emergent pathogen in South Asia, which may become increasingly relevant with the introduction of Vi conjugate vaccines.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Version of record, pdf, 1.5MB, Terms of use)
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- Publisher copy:
- 10.1099/mgen.0.000914
Authors
- Funder identifier:
- https://ror.org/029chgv08
- Grant:
- 215515/Z/19/Z
- Publisher:
- Microbiology Society
- Journal:
- Microbial Genomics More from this journal
- Volume:
- 9
- Issue:
- 1
- Article number:
- 000914
- Publication date:
- 2023-01-06
- Acceptance date:
- 2022-10-18
- DOI:
- EISSN:
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2057-5858
- Pmid:
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36748526
- Language:
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English
- Keywords:
- Pubs id:
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1329707
- Local pid:
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pubs:1329707
- Deposit date:
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2025-01-14
Terms of use
- Copyright holder:
- Pereira-Dias et al.
- Copyright date:
- 2023
- Rights statement:
- © 2023 The Authors. This is an open-access article distributed under the terms of the Creative Commons Attribution License. This article was made open access via a Publish and Read agreement between the Microbiology Society and the corresponding author’s institution.
- Licence:
- CC Attribution (CC BY)
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