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Oral versus intravenous flucytosine in patients with human immunodeficiency virus-associated cryptococcal meningitis.

Abstract:

In a randomized controlled trial of amphotericin B-based therapy for human immunodeficiency virus (HIV)-associated cryptococcal meningitis in Thailand, we also compared the mycological efficacy, toxicity, and pharmacokinetics of oral versus intravenous flucytosine at 100 mg/kg of body weight/day for the initial 2 weeks. Half of 32 patients assigned to the two arms containing flucytosine were randomized to oral and half to intravenous flucytosine. Early fungicidal activity was determined from ...

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Publication status:
Published

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Publisher copy:
10.1128/aac.01188-06

Authors


Brouwer, AE More by this author
van Kan, HJ More by this author
Johnson, E More by this author
Rajanuwong, A More by this author
Teparrukkul, P More by this author
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Journal:
Antimicrobial agents and chemotherapy
Volume:
51
Issue:
3
Pages:
1038-1042
Publication date:
2007-03-05
DOI:
EISSN:
1098-6596
ISSN:
0066-4804
URN:
uuid:429af0fe-86cb-4873-ba00-cd1fca6b47b2
Source identifiers:
71259
Local pid:
pubs:71259

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