- Abstract:
-
The leukocyte common (CD45) Ag is essential for normal T lymphocyte function and alternative splicing at the N terminus of the gene is associated with changes in T cell maturation and differentiation. Recently, a statistically significant association was reported in a large series of human thymus samples between phenotypically abnormal CD45 splicing and the presence of the CC chemokine receptor 5 deletion 32 (CCR5del32) allele, which confers resistance to HIV infection in homozygotes. We show...
Expand abstract - Publisher copy:
- 10.4049/jimmunol.166.10.6144
-
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- Journal:
- Journal of immunology (Baltimore, Md. : 1950)
- Volume:
- 166
- Issue:
- 10
- Pages:
- 6144-6148
- Publication date:
- 2001-05-05
- DOI:
- EISSN:
-
1550-6606
- ISSN:
-
0022-1767
- URN:
-
uuid:429648f6-063d-4e78-87e3-61e8c6b1a318
- Source identifiers:
-
31874
- Local pid:
- pubs:31874
- Copyright date:
- 2001
Journal article
The exon A (C77G) mutation is a common cause of abnormal CD45 splicing in humans.
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