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The exon A (C77G) mutation is a common cause of abnormal CD45 splicing in humans.

Abstract:

The leukocyte common (CD45) Ag is essential for normal T lymphocyte function and alternative splicing at the N terminus of the gene is associated with changes in T cell maturation and differentiation. Recently, a statistically significant association was reported in a large series of human thymus samples between phenotypically abnormal CD45 splicing and the presence of the CC chemokine receptor 5 deletion 32 (CCR5del32) allele, which confers resistance to HIV infection in homozygotes. We show...

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Authors


Tchilian, EZ More by this author
Wallace, DL More by this author
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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
166
Issue:
10
Pages:
6144-6148
Publication date:
2001-05-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:429648f6-063d-4e78-87e3-61e8c6b1a318
Source identifiers:
31874
Local pid:
pubs:31874

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